Researchers at UGA provide first look at protein expression in Chagas disease-causing parasites
Innovations Report
15/07/2005
Major advances have been made in elucidating the genetic processes of Trypanosoma cruzi, the parasite that causes Chagas. This article highlights findings from a study at the University of Georgia, where a research team successfully conducted a survey of protein expression in the four lifecycle stages of the parasite. Their results show distinct protein expression abundance and specificity during different stages of the life cycle.
The research is useful because it could hold the key to a new drug or vaccine target. As touched on in previous posts, current treatments for Chagas aren’t always effective and no vaccine has yet been developed. The problem with developing a vaccine lies in the complexity of this four-stage parasite lifecycle, as it complicates attempts to create an effective therapy that can target and eliminate the parasite in all its different stages. But by examining protein expression along with the recently developed gene map, scientists may be able to make decisions on the viability of specific large gene families as candidates for a vaccine.
This article shows thad advances in bioinformatics such as these are integral to drug and vaccine development for Chagas. Yet we already know that the biggest barrier to Chagas’ vaccine development is not scientific. As Chagas disease afflicts mainly impoverished peoples, there is little financial incentive for drug manufacturers to work invest in R&D for a treatment. Public-private partnerships and market commitments need to be formed in order to ensure that the different private and public goals are aligned towards finding a vaccine.
Nevertheless, these genetic breakthroughs are a hopeful sign in the pursuit of a vaccine for a life-threatening disease that afflicts more than 20 million people around the globe.
Article found at http://www.innovations-report.com/html/reports/life_sciences/report-46584.html
I read this article after I watched a documentary on Chagas on http://topdocumentarystream.com/the-last-kiss/. Appreciate for raising awareness
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